Detoxification Profile

Our bodies must be able to detoxify xenobiotics (environmental toxins), endotoxins (toxins derived from normal physiology and metabolism) and our bodies\' hormones and other potentially toxic compounds. The comprehensive detoxification profile can reflect the degree of toxin exposure and the body\'s ability to handle and metabolize the subsequently generated toxins.

There are two phases, which the body uses for detoxification. These metabolic reactions occur in the liver. They are appropriately named Phase I and Phase II. In general, Phase I processes involve certain types of enzyme systems that modify a toxin so that it can be further degraded and shuttled out of the body through various mechanisms, such as urination, defecation, sweat or volatilization.

Imbalances in the efficiency of these metabolic systems can lead to enhanced free radical damage and depletion of body anti-oxidant stores. They can result in disorders such as arteriosclerosis, multiple allergies, chemical and food sensitivities, inflammatory joint disease, autoimmune processes, neurologic problems, fibromyalgia and chronic fatigue states, to name a few.

The test involves the ingestion of small amounts of acetaminophen (or Tylenol), aspirin, and caffeine. (If you have sensitivities to any of these preparations, please discuss that with the staff.) At appropriate times after ingesting these substances, samples of saliva and urine will be obtained and a blood test will be performed. Complete instructions will be provided for you. From these laboratory specimens, accurate measurements relating to the body\'s ability to adequately detoxify these compounds can be determined. Through evaluation of the measurements, we can determine the efficacy and efficiency of Phase I and Phase II detoxification pathways, including all subcategories of Phase II detoxification, such as glutathione conjugation, glycine conjugation, sulfation, and glucuronidation.

If abnormalities are noted on any of these parameters, there are specific nutritional adjunctive measures, which can bring these patterns back into balance. Test results will be reviewed with you at your follow-up visit, but, if you need more information, please do not hesitate to ask questions during the interim.

Dale Guyer, M.D.