Co-Enzyme Q10 (CoQ10)

Co-Enzyme Q10 is a metabolic intermediate that our body manufactures for use in energy metabolism. It is also acquired from our diets. Many studies have shown that, as we age, our capacity to manufacture this compound diminishes. It is used in the final stages of a process referred to oxidative phosphorylation, which occurs in the mitochondrial membrane of all of our cells. These are the organelles responsible for the production of energy.

The therapeutic use of Co-Enzyme Q10 is multi-focal:

It has been shown to be extremely useful in congestive heart failure and various types of associated cardiomyopathies. As a matter of fact, in some studies published in Japan, patients awaiting cardiac transplant surgery were put on Co-Enzyme Q10. Many patients were symptomatically improved enough to be removed from the transplant list. In my clinical experiences, I have seen dramatic effects of Co-Enzyme Q10, as it relates to increasing heart function. Oftentimes, this therapy would be accompanied by other adjunctive nutritional approaches, such as the amino acids taurine, carnitine, and other supplements, such as pantethine.

There has also been a lot of interest in the use of Co-Enzyme Q10 as an adjunctive therapy for various types of cancer, with a specific focus on breast cancer. It was noted in some early studies that co-administration of Co-Enzyme Q10 and Adriamycin (a standard, conventional chemotherapy treatment for breast cancer) showed an enhanced survival rate.

In addition to the observation that the Co-Enzyme Q10 seems to prevent (or at least diminish) the cardio toxic effects of certain chemotherapeutic drugs such as Adriamycin, administration of Co-Enzyme Q10 by itself was shown to enhance survivability in breast cancer patients. In some cases, it was associated with remission. The doses used in these studies were somewhat high, at 400 mg daily; however, no side effects were reported.

Co-Enzyme Q10 has also been shown to be effective in decreasing free radical-associated pathology in conjunction with strenuous physical activity. Therefore, it has found favor among many professional athletes.

Co-Enzyme Q10 tends to lower blood pressure and cholesterol levels and improve situations as diverse as periodontal disease and immune function. Oftentimes, patients with chronic fatigue symptoms will also feel an improved sense of well being and have more energy when taking this supplement.

There have not been significant side effects associated with the use of Co-Enzyme Q10.

The cost of Co-Enzyme Q10 is somewhat high. There are also many grades of Co-Enzyme Q10. It is often worthwhile to utilize resources, which supply the nutrient for research studies. Please consult our office or your local health food store proprietor for information on high quality Co-Enzyme Q10 sources.

Dale Guyer, M.D.